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PhD Vacancy at University of Gottingen, Germany

 

The Center for Molecular Physiology of the Brain (CMPB) is seeking a PhD student (molecular biology and cell biology techniques) for the project: Molecular mechanisms in synapse formation and their alteration in Rett Syndrome fixed-term appointment | salary according to TV-L

About us : The University Medical Center Göttingen is a tertiary care center and offers great development potential. Its 7000 employees work in over 60 departments and facilities to provide top-quality patient care, excellent research and modern teaching. Göttingen, “City of Science”, lies near the center of Germany and is home to northern Germany’s only University of Excellence, which is embedded in the city’s attractive network of scientific research facilities.

Your profile : In Rett Syndrome, the loss of the transcriptional repressor protein MeCP2 leads to changes in the expression of neuronal proteins, resulting in a reduction in synaptic density and function, and, on the neurological level, in mental retardation and autism spectrum behavior.

What we are Looking for :

 

 

  • We will use advanced microscopy techniques (FRET/FLIM, photoactivation imaging) in primary neuronal culture of a Rett Syndrome mouse genetic model to investigate changes in key mechanisms involved in the assembly of functional synapses and the organization of synaptic membranes. These will include dendritic motility, axonal branching, the transport of synaptic components in neurites and the formation and stabilization of axodendritic contacts.
  • We are looking for a motivated team member with basic experience in molecular biology and cell biology techniques. Specific experience in fluorescence microscopy and neurobiology is considered an advantage.
  • Women are especially encouraged to apply. Handicapped applicants with equal qualifications will be given preferential treatment.

We look forward to receiving your application by E-Mail till August 22nd, 2011.
Please note : The documents cannot be returned and will be destroyed at the end of the application process.

Prof. Fred Wouters
Dept. of Neuro- and Sensory Physiology
D-37099 Göttingen
Germany
Phone: +49 (0) 551/39-12368
Fax: +49 (0) 551/39-12346
E-Mail : fred.wouters@gwdg.de
Website : http://www.cmpb.de

Deadline : 22.08.2011




Thursday , 4   August , 2011